Linked Life Data

12137764

Source:http://linkedlifedata.com/resource/pubmed/id/12137764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-7-24
pubmed:abstractText
Previous electrophysiological studies have demonstrated that tetrodotoxin-resistant (TTX-R) sodium channels contribute to action potential electrogenesis and conduction along non-myelinated PNS axons. Moreover, recent work has established that TTX-R sodium channels play a major role in the generation of action potentials in the terminals of non-myelinated nociceptive axons innervating the cornea. We have utilized subtype-specific antibodies to sodium channels Na(v)1.8 and Na(v)1.9 to examine the molecular identity of the TTX-R sodium channels that are present in these axons. Both Na(v)1.8 and Na(v)1.9 sodium channels are expressed diffusely along the entire lengths of non-myelinated corneal axons, from the nerve plexus at the corneoscleral limbus to the distal corneal leash fibers. Moreover, both Na(v)1.8 and Na(v)1.9 are localized at the bulb-like nerve terminals of the leash fibers within the superficial epithelial layers of the cornea. These observations suggest that both TTX-R sodium channels Na(v)1.8 and Na(v)1.9 contribute to the electrogenesis of non-myelinated axons of the cornea.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Molecular identities of two tetrodotoxin-resistant sodium channels in corneal axons.
pubmed:affiliation
Department of Neurology and Paralyzed Veterans of America/Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven, CT 06510, USA. joel.black@yale.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't