Source:http://linkedlifedata.com/resource/pubmed/id/12135816
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2002-7-23
|
| pubmed:abstractText |
Thiopurine S-methyltransferase (TPMT), which exhibits autosomal codominant polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine and azathioprine. Decreased activity of TPMT is associated with severe hematopoietic toxicity after administration of standard doses of these drugs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0009-8981
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
323
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
147-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12135816-6-Mercaptopurine,
pubmed-meshheading:12135816-Asian Continental Ancestry Group,
pubmed-meshheading:12135816-Chromatography, High Pressure Liquid,
pubmed-meshheading:12135816-Genotype,
pubmed-meshheading:12135816-Humans,
pubmed-meshheading:12135816-Methylation,
pubmed-meshheading:12135816-Methyltransferases,
pubmed-meshheading:12135816-Molecular Structure,
pubmed-meshheading:12135816-Sensitivity and Specificity
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.
|
| pubmed:affiliation |
Department of Pharmacy, Faculty of Medicine, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|