Source:http://linkedlifedata.com/resource/pubmed/id/12134096
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2002-7-22
|
| pubmed:abstractText |
Blockade of CD40 ligand (CD40L; CD154, gp39) is a potential treatment for autoimmune disease and allograft rejection. However, CD40L-/- mice are capable of mobilizing cellular immune responses to viral, parasitic, and intracellular bacterial infections as well as rejecting skin grafts with nearly the same efficiency as wild-type mice. CD40L-deficient mice (CD40L-/-) or wild-type mice treated with anti-CD40L develop chronic vasculopathy only 8 weeks after allogeneic heart transplantation. To overcome CD40L-independent immune responses, we used anti-lymphocyte function-associated antigen monoclonal antibody (LFA)-1, which has previously been shown to inhibit CD8+ immune responses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0041-1337
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
35-41
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12134096-Animals,
pubmed-meshheading:12134096-Antibodies, Monoclonal,
pubmed-meshheading:12134096-CD40 Ligand,
pubmed-meshheading:12134096-Cell Division,
pubmed-meshheading:12134096-Chronic Disease,
pubmed-meshheading:12134096-Graft Rejection,
pubmed-meshheading:12134096-Graft Survival,
pubmed-meshheading:12134096-Heart Transplantation,
pubmed-meshheading:12134096-Male,
pubmed-meshheading:12134096-Mice,
pubmed-meshheading:12134096-Mice, Inbred BALB C,
pubmed-meshheading:12134096-Mice, Inbred C3H,
pubmed-meshheading:12134096-Mice, Inbred C57BL,
pubmed-meshheading:12134096-Mice, Knockout,
pubmed-meshheading:12134096-Postoperative Complications,
pubmed-meshheading:12134096-Skin Transplantation,
pubmed-meshheading:12134096-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12134096-Transplantation, Homologous,
pubmed-meshheading:12134096-Vascular Diseases
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.
|
| pubmed:affiliation |
Department of Nephrology and Transplantation, University Hospital, Lund University, Malmö, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|