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pubmed-article:12131682pubmed:abstractTextCytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 play significant roles in the inflammatory and immune responses that mediate allograft rejection. The presence of a G-->A polymorphism at position -308 in the promoter region of the TNF-alpha gene increased its transcription 6- to 7-fold. A similar polymorphism at position -1082 of the IL-10 promoter results in decreased production of IL-10 protein. In this study we have determined whether the single nucleotide polymorphisms in the promoter regions of the TNF-alpha and IL-10 genes can predict the outcome of the allograft in liver recipients.lld:pubmed
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pubmed-article:12131682pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:12131682pubmed:articleTitleInvestigation of promoter polymorphisms in the tumor necrosis factor-alpha and interleukin-10 genes in liver transplant patients.lld:pubmed
pubmed-article:12131682pubmed:affiliationDepartment of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA. fernande@umdnj.edulld:pubmed
pubmed-article:12131682pubmed:publicationTypeJournal Articlelld:pubmed
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