rdf:type |
|
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0019704,
umls-concept:C0035820,
umls-concept:C0039194,
umls-concept:C0042776,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0205369,
umls-concept:C1257986,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1879547,
umls-concept:C2698600
|
pubmed:issue |
10
|
pubmed:dateCreated |
2002-7-19
|
pubmed:abstractText |
The CD4 T cells in mucosal subepithelia are the first cells to become infected during sexual transmission of HIV-1. Dendritic cells (DC) are located in the same area and are known to play a central role in antiviral immune responses. However, extensive viral replication, syncytia formation and cell death follows the interaction between T cells and DC previously exposed to HIV-1. Despite this, anti-HIV responses are generated that control viremia following acute infection.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0269-9370
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
5
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1319-29
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:12131208-Antigen Presentation,
pubmed-meshheading:12131208-Apoptosis,
pubmed-meshheading:12131208-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12131208-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12131208-Dendritic Cells,
pubmed-meshheading:12131208-HIV Antigens,
pubmed-meshheading:12131208-HIV-1,
pubmed-meshheading:12131208-HeLa Cells,
pubmed-meshheading:12131208-Humans,
pubmed-meshheading:12131208-Immunity, Cellular,
pubmed-meshheading:12131208-Immunologic Memory,
pubmed-meshheading:12131208-Lymphocyte Activation
|
pubmed:year |
2002
|
pubmed:articleTitle |
Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus.
|
pubmed:affiliation |
The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York 10021, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|