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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-7-19
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pubmed:abstractText |
Recent American Heart Association guidelines highlight the paucity of data on effectiveness and/or mechanisms underlying use of beta-adrenergic receptor (beta AR) antagonists after acute coronary syndromes in patients subsequently undergoing revascularization. It is important to assess whether beta AR antagonists might protect the heart and improve ventricular function in this scenario. The authors therefore used esmolol (an ultra-short-acting beta AR antagonist) to determine whether beta AR antagonist treatment improves left ventricular function in a canine model of acute reversible coronary ischemia followed by coronary reperfusion during cardiopulmonary bypass (CPB). The authors also tested whether the mechanism includes preserved beta AR signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
162-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12131118-Adenylate Cyclase,
pubmed-meshheading:12131118-Adrenergic beta-Antagonists,
pubmed-meshheading:12131118-Animals,
pubmed-meshheading:12131118-Cardiopulmonary Bypass,
pubmed-meshheading:12131118-Catecholamines,
pubmed-meshheading:12131118-Dogs,
pubmed-meshheading:12131118-Models, Animal,
pubmed-meshheading:12131118-Myocardial Revascularization,
pubmed-meshheading:12131118-Propanolamines,
pubmed-meshheading:12131118-Receptors, Adrenergic, beta,
pubmed-meshheading:12131118-Systole,
pubmed-meshheading:12131118-Ventricular Function, Left
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pubmed:year |
2002
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pubmed:articleTitle |
Esmolol improves left ventricular function via enhanced beta-adrenergic receptor signaling in a canine model of coronary revascularization.
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pubmed:affiliation |
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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