Linked Life Data

12128005

Source:http://linkedlifedata.com/resource/pubmed/id/12128005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-7-19
pubmed:abstractText
The neural adaptations involved in initiating and maintaining the long-term consequences of utilizing drugs of abuse are the subject of intense investigation. It is commonly suggested that the neural plasticity mechanisms underlying physiological phenomena such as learning and memory may also be engaged when drug addiction occurs. The effect of cocaine on one prominent cellular mechanism for learning/memory, long-term potentiation (LTP), was assessed in the CA1 region of the rat hippocampus. Hippocampal slices obtained from animals treated in vivo for five days with cocaine (15 mg/kg i.p., daily) exhibited enhanced LTP vs saline treated controls. We suggest that this example of cocaine-induced enhancement of LTP provides an example of how synaptic plasticity mechanisms may be altered in a manner that contributes to the behavioral outcomes expressed, following exposure to psychostimulants.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1039-42
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Enhancement of long-term potentiation in the rat hippocampus following cocaine exposure.
pubmed:affiliation
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58102, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't