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pubmed-article:12127554pubmed:abstractTextWe report the findings of three new cases of a distinct clinicopathologic natural killer (NK) cell malignancy characterized by cutaneous, nodal and bone marrow infiltration by CD3-CD4+CD56+ NK blastic cells. Tumor cells were detected in bone marrow and in peripheral blood smears and showed finely distributed nuclear chromatin with nucleoli and a moderate amount of cytoplasm. Epstein-Barr virus (EBV) DNA was negative in the two tested cases. The immunophenotypes determined by flow cytometry were identical concerning mCD3-cytCD3-CD4+weakCD56+ HLA-DR+. The TCR was in germline configuration in the two cases tested. NK cell activity was demonstrated only in one out of the two cases tested. The negative reactions with alpha-naphthyl-acetate-esterase (ANAE), CD11b and CD14 strongly suggested that the tumor cells were not of the monocytic lineage.lld:pubmed
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pubmed-article:12127554pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:12127554pubmed:year2002lld:pubmed
pubmed-article:12127554pubmed:articleTitleBlastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity.lld:pubmed
pubmed-article:12127554pubmed:affiliationDepartment of Clinical Medicine, School of Medicine Ribeirão Preto-USP, Ribeirão Preto, SP, Brazil. rpfalcao@fmrp.usp.brlld:pubmed
pubmed-article:12127554pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12127554pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed