Source:http://linkedlifedata.com/resource/pubmed/id/12127554
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2002-7-19
|
| pubmed:abstractText |
We report the findings of three new cases of a distinct clinicopathologic natural killer (NK) cell malignancy characterized by cutaneous, nodal and bone marrow infiltration by CD3-CD4+CD56+ NK blastic cells. Tumor cells were detected in bone marrow and in peripheral blood smears and showed finely distributed nuclear chromatin with nucleoli and a moderate amount of cytoplasm. Epstein-Barr virus (EBV) DNA was negative in the two tested cases. The immunophenotypes determined by flow cytometry were identical concerning mCD3-cytCD3-CD4+weakCD56+ HLA-DR+. The TCR was in germline configuration in the two cases tested. NK cell activity was demonstrated only in one out of the two cases tested. The negative reactions with alpha-naphthyl-acetate-esterase (ANAE), CD11b and CD14 strongly suggested that the tumor cells were not of the monocytic lineage.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0145-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
803-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12127554-Adolescent,
pubmed-meshheading:12127554-Aged,
pubmed-meshheading:12127554-Antigens, CD56,
pubmed-meshheading:12127554-Antigens, Neoplasm,
pubmed-meshheading:12127554-Child,
pubmed-meshheading:12127554-HLA-DR Antigens,
pubmed-meshheading:12127554-Herpesvirus 4, Human,
pubmed-meshheading:12127554-Humans,
pubmed-meshheading:12127554-Immunophenotyping,
pubmed-meshheading:12127554-Killer Cells, Natural,
pubmed-meshheading:12127554-Leukemia, Lymphoid,
pubmed-meshheading:12127554-Leukemic Infiltration,
pubmed-meshheading:12127554-Lymphatic Diseases,
pubmed-meshheading:12127554-Lymphoma,
pubmed-meshheading:12127554-Male,
pubmed-meshheading:12127554-Neoplastic Stem Cells,
pubmed-meshheading:12127554-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12127554-Skin,
pubmed-meshheading:12127554-Splenomegaly
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Blastic CD4 NK cell leukemia/lymphoma: a distinct clinical entity.
|
| pubmed:affiliation |
Department of Clinical Medicine, School of Medicine Ribeirão Preto-USP, Ribeirão Preto, SP, Brazil. rpfalcao@fmrp.usp.br
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|