Source:http://linkedlifedata.com/resource/pubmed/id/12127512
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2002-7-19
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| pubmed:abstractText |
We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2097-100
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12127512-Animals,
pubmed-meshheading:12127512-Antineoplastic Agents,
pubmed-meshheading:12127512-Carcinoma,
pubmed-meshheading:12127512-Colon,
pubmed-meshheading:12127512-Colonic Neoplasms,
pubmed-meshheading:12127512-Humans,
pubmed-meshheading:12127512-Mice,
pubmed-meshheading:12127512-Mice, Nude,
pubmed-meshheading:12127512-Molecular Structure,
pubmed-meshheading:12127512-Structure-Activity Relationship,
pubmed-meshheading:12127512-Sulfonamides,
pubmed-meshheading:12127512-Tumor Cells, Cultured
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.
|
| pubmed:affiliation |
Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, 300-2635, Ibaraki, Japan. t-owa@hhc.eisai.co.jp
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| pubmed:publicationType |
Journal Article
|