Linked Life Data

12127069

Source:http://linkedlifedata.com/resource/pubmed/id/12127069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-7-19
pubmed:abstractText
Oct2 transcription factors of the catfish (Ictalurus punctatus) are expressed as alternatively spliced alpha and beta isoforms. Functional analysis revealed an N-terminal glutamine (Q)-rich transactivation domain common to both isoforms of catfish Oct2. A C-terminal proline, serine, threonine (PST)-rich activation domain was identified exclusively in the beta isoform. Activation domains of fish and mammalian Oct2 showed cell type- and species-specific activity correlated with their biochemical composition (Q-rich vs PST-rich). In contrast the activation domains of the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator of fish and mammals showed no correlation of activity with biochemical composition or species of origin. Although isolated catfish Oct2 activation domains were unable to drive transcription from a site 1.9kb distal to the promoter, Oct2beta activated transcription from both an IgH enhancer and an array of octamer motifs at this distal position. The properties of catfish Oct2 activation domains differ depending on whether they are studied in isolation or as components of the intact transcription factor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-9861
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
404
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-61
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12127069-Alternative Splicing, pubmed-meshheading:12127069-Animals, pubmed-meshheading:12127069-Aryl Hydrocarbon Receptor Nuclear Translocator, pubmed-meshheading:12127069-Catfishes, pubmed-meshheading:12127069-DNA-Binding Proteins, pubmed-meshheading:12127069-Enhancer Elements, Genetic, pubmed-meshheading:12127069-Genes, Immunoglobulin, pubmed-meshheading:12127069-Mice, pubmed-meshheading:12127069-Organic Cation Transport Proteins, pubmed-meshheading:12127069-Protein Isoforms, pubmed-meshheading:12127069-Protein Structure, Tertiary, pubmed-meshheading:12127069-Receptors, Aryl Hydrocarbon, pubmed-meshheading:12127069-Recombinant Fusion Proteins, pubmed-meshheading:12127069-Species Specificity, pubmed-meshheading:12127069-Tissue Distribution, pubmed-meshheading:12127069-Transcription Factors, pubmed-meshheading:12127069-Transcriptional Activation
pubmed:year
2002
pubmed:articleTitle
Oct2 transcription factor of a teleost fish: activation domains and function from an enhancer.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, The Medical University of South Carolina, Charleston, SC 29425, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.