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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-19
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pubmed:abstractText |
Inflammatory bowel disease (IBD) is a multifactorial disease with a significant genetic background. Evidence is accumulating that molecules such as CD14, which interact with luminal bacterial constituents, are involved in the pathogenesis. It has recently been shown that the T allele of the 5'-flanking region of the CD14 gene at position -159 is related to high expression of CD14. In further exploring the genetic background of IBD, we investigated this novel polymorphism of CD14 gene in patients with ulcerative colitis or Crohn disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-5521
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-704
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12126249-Adult,
pubmed-meshheading:12126249-Aged,
pubmed-meshheading:12126249-Antigens, CD14,
pubmed-meshheading:12126249-Base Sequence,
pubmed-meshheading:12126249-Case-Control Studies,
pubmed-meshheading:12126249-Colitis, Ulcerative,
pubmed-meshheading:12126249-Confidence Intervals,
pubmed-meshheading:12126249-Crohn Disease,
pubmed-meshheading:12126249-Female,
pubmed-meshheading:12126249-Gene Expression,
pubmed-meshheading:12126249-Genetic Predisposition to Disease,
pubmed-meshheading:12126249-Genotype,
pubmed-meshheading:12126249-Humans,
pubmed-meshheading:12126249-Male,
pubmed-meshheading:12126249-Middle Aged,
pubmed-meshheading:12126249-Molecular Sequence Data,
pubmed-meshheading:12126249-Polymerase Chain Reaction,
pubmed-meshheading:12126249-Polymorphism, Genetic,
pubmed-meshheading:12126249-Probability,
pubmed-meshheading:12126249-Promoter Regions, Genetic,
pubmed-meshheading:12126249-Reference Values,
pubmed-meshheading:12126249-Sensitivity and Specificity
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pubmed:year |
2002
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pubmed:articleTitle |
Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14.
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pubmed:affiliation |
Dept of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan. nobana@int3.med.tohoku.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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