Source:http://linkedlifedata.com/resource/pubmed/id/12124871
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2002-7-18
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pubmed:abstractText |
Antibodies directed against an epitope motif on CENP-A have been shown to cross-react with mimotopes on other autoantigens and on Epstein-Barr nuclear antigen 1 (EBNA-1), suggesting a molecular mimicry. We describe here the gradual development of an anticentromere immune response in a patient with systemic sclerosis, which started from an antihistone response and was not mediated by molecular mimicry. Via an epitope on histone H3, the antibody response spread to a homologous epitope in the H3 homology domain of CENP-A. This was followed by an intramolecular epitope spreading to N-terminal peptides of CENP-A containing the known epitope motif G-P-X(1)-R-X(2). From there it spread to corresponding epitopes on CENP-B and to mimotopes of the major CENP-A epitope motif on other autoantigens including EBNA-1. Whether the D-penicillamine treatment received by this patient was involved in the triggering of this cascade remains a matter of speculation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CENPB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Centromere Protein B,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/centromere protein A
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1866-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12124871-Adult,
pubmed-meshheading:12124871-Autoantigens,
pubmed-meshheading:12124871-Centromere Protein B,
pubmed-meshheading:12124871-Chromatin,
pubmed-meshheading:12124871-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:12124871-DNA-Binding Proteins,
pubmed-meshheading:12124871-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12124871-Epitopes,
pubmed-meshheading:12124871-Female,
pubmed-meshheading:12124871-Humans,
pubmed-meshheading:12124871-Scleroderma, Systemic
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pubmed:year |
2002
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pubmed:articleTitle |
Development of a CENP-A/CENP-B-specific immune response in a patient with systemic sclerosis.
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pubmed:affiliation |
Institute of Molecular Genetics, University of Heidelberg, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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