| pubmed-article:12123809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C0205042 | lld:lifeskim |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C0015520 | lld:lifeskim |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12123809 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12123809 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:12123809 | pubmed:dateCreated | 2002-7-18 | lld:pubmed |
| pubmed-article:12123809 | pubmed:abstractText | Factor Xa-induced stimulation of coronary artery smooth muscle cells (CASMC) was investigated by analyzing [(3)H]thymidine incorporation, cell proliferation, and ERK-1/2 activation. Exposure of the cells to factor Xa evoked a time-dependent activation of ERK-1/2 with increased [(3)H]thymidine incorporation and cell proliferation. The factor Xa-induced ERK-1/2 activation was not desensitized by preincubation of the cells with thrombin. However, ERK-1/2 activation was markedly attenuated by prior exposure of the cells to protease-activated receptor-2 (PAR-2) activating peptide, SLIGKV. The mitogenic effect of factor Xa was significantly reduced in the presence of anti-PAR-2 monoclonal antibody. Several lines of experimental evidence indicate that factor Xa-induced mitogenesis of CASMC is a cellular process mediated by PAR-2 activation. | lld:pubmed |
| pubmed-article:12123809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12123809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12123809 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12123809 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:12123809 | pubmed:author | pubmed-author:HwangKi... | lld:pubmed |
| pubmed-article:12123809 | pubmed:author | pubmed-author:KooBon HunBH | lld:pubmed |
| pubmed-article:12123809 | pubmed:author | pubmed-author:ChungKwang... | lld:pubmed |
| pubmed-article:12123809 | pubmed:author | pubmed-author:KimDoo SikDS | lld:pubmed |
| pubmed-article:12123809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12123809 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:12123809 | pubmed:volume | 523 | lld:pubmed |
| pubmed-article:12123809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12123809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12123809 | pubmed:pagination | 85-9 | lld:pubmed |
| pubmed-article:12123809 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12123809 | pubmed:meshHeading | pubmed-meshheading:12123809... | lld:pubmed |
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| pubmed-article:12123809 | pubmed:meshHeading | pubmed-meshheading:12123809... | lld:pubmed |
| pubmed-article:12123809 | pubmed:meshHeading | pubmed-meshheading:12123809... | lld:pubmed |
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| pubmed-article:12123809 | pubmed:meshHeading | pubmed-meshheading:12123809... | lld:pubmed |
| pubmed-article:12123809 | pubmed:meshHeading | pubmed-meshheading:12123809... | lld:pubmed |
| pubmed-article:12123809 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12123809 | pubmed:articleTitle | Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2. | lld:pubmed |
| pubmed-article:12123809 | pubmed:affiliation | Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, 120-749, Seoul, South Korea. | lld:pubmed |
| pubmed-article:12123809 | pubmed:publicationType | Journal Article | lld:pubmed |
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