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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2002-7-18
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pubmed:abstractText |
Factor Xa-induced stimulation of coronary artery smooth muscle cells (CASMC) was investigated by analyzing [(3)H]thymidine incorporation, cell proliferation, and ERK-1/2 activation. Exposure of the cells to factor Xa evoked a time-dependent activation of ERK-1/2 with increased [(3)H]thymidine incorporation and cell proliferation. The factor Xa-induced ERK-1/2 activation was not desensitized by preincubation of the cells with thrombin. However, ERK-1/2 activation was markedly attenuated by prior exposure of the cells to protease-activated receptor-2 (PAR-2) activating peptide, SLIGKV. The mitogenic effect of factor Xa was significantly reduced in the presence of anti-PAR-2 monoclonal antibody. Several lines of experimental evidence indicate that factor Xa-induced mitogenesis of CASMC is a cellular process mediated by PAR-2 activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
523
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12123809-Cell Division,
pubmed-meshheading:12123809-Coronary Vessels,
pubmed-meshheading:12123809-Enzyme Activation,
pubmed-meshheading:12123809-Factor Xa,
pubmed-meshheading:12123809-Humans,
pubmed-meshheading:12123809-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12123809-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12123809-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12123809-Mitogens,
pubmed-meshheading:12123809-Muscle, Smooth, Vascular,
pubmed-meshheading:12123809-Receptor, PAR-2,
pubmed-meshheading:12123809-Receptors, Thrombin
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pubmed:year |
2002
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pubmed:articleTitle |
Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2.
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pubmed:affiliation |
Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, 120-749, Seoul, South Korea.
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pubmed:publicationType |
Journal Article
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