| pubmed-article:12123444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12123444 | lifeskim:mentions | umls-concept:C0376624 | lld:lifeskim |
| pubmed-article:12123444 | lifeskim:mentions | umls-concept:C0205242 | lld:lifeskim |
| pubmed-article:12123444 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:12123444 | lifeskim:mentions | umls-concept:C0025543 | lld:lifeskim |
| pubmed-article:12123444 | lifeskim:mentions | umls-concept:C0540301 | lld:lifeskim |
| pubmed-article:12123444 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12123444 | pubmed:dateCreated | 2002-7-18 | lld:pubmed |
| pubmed-article:12123444 | pubmed:abstractText | Escherichia coli O157:H7 causes diarrhoea, haemorrhagic colitis, and the haemolytic uraemic syndrome. We have identified a protein of previously unknown function encoded on the pO157 virulence plasmid of E. coli O157:H7, which is the first described protease that specifically cleaves C1 esterase inhibitor (C1-INH), a member of the serine protease inhibitor family. The protein, named StcE for secreted protease of C1 esterase inhibitor from EHEC (formerly Tagn), cleaves C1-INH to produce (unique) approximately 60-65 kDa fragments. StcE does not digest other serine protease inhibitors, extracellular matrix proteins or universal protease targets. We also observed that StcE causes the aggregation of cultured human T cells but not macrophage-like cells or B cells. Substitution of aspartic acid for glutamic acid at StcE position 435 within the consensus metalloprotease active site ablates its abilities to digest C1-INH and to aggregate T cells. StcE is secreted by the etp type II secretion pathway encoded on pO157, and extracellular StcE levels are positively regulated by the LEE-encoded regulator, Ler. StcE antigen and activity were detected in the faeces of a child with an E. coli O157:H7 infection, demonstrating the expression of StcE during human disease. Cleavage of C1-INH by StcE could plausibly cause localized pro-inflammatory and coagulation responses resulting in tissue damage, intestinal oedema and thrombotic abnormalities. | lld:pubmed |
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| pubmed-article:12123444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12123444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12123444 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12123444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12123444 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12123444 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:KaperJames... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:TarrPhillip... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:TorresAlfredo... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:LathemWyndham... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:GrysThomas... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:WitowskiSarah... | lld:pubmed |
| pubmed-article:12123444 | pubmed:author | pubmed-author:WelchRodney... | lld:pubmed |
| pubmed-article:12123444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12123444 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:12123444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12123444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12123444 | pubmed:pagination | 277-88 | lld:pubmed |
| pubmed-article:12123444 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12123444 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12123444 | pubmed:articleTitle | StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor. | lld:pubmed |
| pubmed-article:12123444 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA. | lld:pubmed |
| pubmed-article:12123444 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12123444 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12123444 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:710 | entrezgene:pubmed | pubmed-article:12123444 | lld:entrezgene |
| family:PF10462.4 | family:pubmed | pubmed-article:12123444 | lld:pfam |
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