12121944

Source:http://linkedlifedata.com/resource/pubmed/id/12121944

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003308, umls-concept:C0005528, umls-concept:C0005854, umls-concept:C0041242, umls-concept:C0205409, umls-concept:C1138842
pubmed:issue	8
pubmed:dateCreated	2002-7-17
pubmed:abstractText	We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 NS 41863
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-10049901, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-15012493, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-1551872, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-1762091, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-1850135, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-2338547, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-2611685, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-3935042, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-6390082, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-6822610, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-6822623, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-7748196, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-7822099, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-7912427, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-8246142, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-8370768, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-8574648, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-8801538, http://linkedlifedata.com/resource/pubmed/commentcorrection/12121944-8930334
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents, http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0066-4804
pubmed:author	pubmed-author:BanksWilliam AWA, pubmed-author:BrownRobert LRL, pubmed-author:ChenZhi-YuanZY, pubmed-author:ClevelandThomas ETE, pubmed-author:NiehoffMichael LML
pubmed:issnType	Print
pubmed:volume	46
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2633-5
pubmed:dateRevised	2010-9-14
pubmed:meshHeading	pubmed-meshheading:12121944-Algorithms, pubmed-meshheading:12121944-Animals, pubmed-meshheading:12121944-Antifungal Agents, pubmed-meshheading:12121944-Blood-Brain Barrier, pubmed-meshheading:12121944-Brain, pubmed-meshheading:12121944-Injections, Intravenous, pubmed-meshheading:12121944-Mice, pubmed-meshheading:12121944-Mice, Inbred ICR, pubmed-meshheading:12121944-Molecular Weight, pubmed-meshheading:12121944-Trypsin Inhibitors, pubmed-meshheading:12121944-Zea mays
pubmed:year	2002
pubmed:articleTitle	Transport of an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier.
pubmed:affiliation	Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical Center, 915 N Grand Boulevard, St. Louis, MO 63106, USA. bankswa@slu.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.