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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-17
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pubmed:abstractText |
Complement and Fc receptor (FcR)-positive cells mediate effector functions of antibodies. Antibody-dependent immunity against the melanosome membrane glycoprotein gp75/tyrosinase-related protein-1 (TYRP-1) of melanocytes leads to autoimmune hypopigmentation (vitiligo) in mice. Hypopigmentation occurred in mice deficient in activating FcR containing the common gamma subunit (Fc gamma R gamma(-/-)) and in mice deficient in the C3 complement component. Mice doubly deficient in both Fc gamma R gamma and C3 did not develop hypopigmentation, suggesting that complement and Fc gamma R formed redundant mechanisms. Following passive immunization with antibody, no further adaptive immune responses were required. Chimeric Fc gamma R gamma(-/-),C3(-/-) mice reconstituted with bone marrow from either Fc gamma R gamma(-/-) or C3(-/-) mice or adoptively transferred with Fc gamma R gamma(+/-) macrophages did develop antibody-mediated hypopigmentation. Thus, either complement or macrophages expressing activating Fc gamma R can independently and alternatively mediate disease in a model of autoimmune vitiligo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:BergtoldAmyA,
pubmed-author:CarrollMichael CMC,
pubmed-author:ClynesRaphael ARA,
pubmed-author:FerroneCristina RCR,
pubmed-author:GoldbergStacie MSM,
pubmed-author:HoughtonAlan NAN,
pubmed-author:MaMingheM,
pubmed-author:MoroiYoichiY,
pubmed-author:PeralesMiguel AngelMA,
pubmed-author:RavetchJeffrey VJV,
pubmed-author:TrckaJiriJ
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
861-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12121667-Adoptive Transfer,
pubmed-meshheading:12121667-Animals,
pubmed-meshheading:12121667-Complement Activation,
pubmed-meshheading:12121667-Complement C3,
pubmed-meshheading:12121667-Genotype,
pubmed-meshheading:12121667-Immunization, Passive,
pubmed-meshheading:12121667-Macrophages,
pubmed-meshheading:12121667-Melanocytes,
pubmed-meshheading:12121667-Membrane Glycoproteins,
pubmed-meshheading:12121667-Mice,
pubmed-meshheading:12121667-Mice, Inbred C57BL,
pubmed-meshheading:12121667-Mice, Knockout,
pubmed-meshheading:12121667-Oxidoreductases,
pubmed-meshheading:12121667-Receptors, Fc,
pubmed-meshheading:12121667-Recombinant Fusion Proteins,
pubmed-meshheading:12121667-Vitiligo
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pubmed:year |
2002
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pubmed:articleTitle |
Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo.
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pubmed:affiliation |
The Swim Across America Laboratory, Memorial Sloan-Kettering Cancer Center and Weill Graduate School of Cornell University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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