12118026

Source:http://linkedlifedata.com/resource/pubmed/id/12118026

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0022625, umls-concept:C0025519, umls-concept:C0123931, umls-concept:C1709059
pubmed:issue	14
pubmed:dateCreated	2002-7-15
pubmed:abstractText	Irinotecan (CPT-11) is a prodrug of SN-38 and has been registered for the treatment of advanced colorectal cancer. It is converted by the cytochrome P450 3A4 isozyme (CYP3A4) into several inactive metabolites, including 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]-carbonyloxycamptothecin (APC). To investigate the role of CYP3A4 in irinotecan pharmacology, we evaluated the consequences of simultaneous treatment of irinotecan with a potent enzyme inhibitor, ketoconazole, in a group of cancer patients.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309333
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Ketoconazole, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs, http://linkedlifedata.com/resource/pubmed/chemical/irinotecan
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0732-183X
pubmed:author	pubmed-author:KehrerDiederik F SDF, pubmed-author:MathijssenRon H JRH, pubmed-author:SparreboomAlexA, pubmed-author:VerweijJaapJ, pubmed-author:de BruijnPeterP
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3122-9
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:12118026-Adult, pubmed-meshheading:12118026-Aged, pubmed-meshheading:12118026-Antifungal Agents, pubmed-meshheading:12118026-Antineoplastic Agents, Phytogenic, pubmed-meshheading:12118026-Camptothecin, pubmed-meshheading:12118026-Chromatography, High Pressure Liquid, pubmed-meshheading:12118026-Colorectal Neoplasms, pubmed-meshheading:12118026-Cross-Over Studies, pubmed-meshheading:12118026-Cytochrome P-450 CYP3A, pubmed-meshheading:12118026-Cytochrome P-450 Enzyme System, pubmed-meshheading:12118026-Drug Administration Schedule, pubmed-meshheading:12118026-Enzyme Inhibitors, pubmed-meshheading:12118026-Female, pubmed-meshheading:12118026-Humans, pubmed-meshheading:12118026-Ketoconazole, pubmed-meshheading:12118026-Leukocyte Count, pubmed-meshheading:12118026-Leukocytes, pubmed-meshheading:12118026-Liver, pubmed-meshheading:12118026-Male, pubmed-meshheading:12118026-Middle Aged, pubmed-meshheading:12118026-Mixed Function Oxygenases, pubmed-meshheading:12118026-Neutrophils, pubmed-meshheading:12118026-Prodrugs
pubmed:year	2002
pubmed:articleTitle	Modulation of irinotecan metabolism by ketoconazole.
pubmed:affiliation	Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek), University Hospital Rotterdam, The Netherlands.
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial