Source:http://linkedlifedata.com/resource/pubmed/id/12117107
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2002-7-15
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| pubmed:abstractText |
The pharmacokinetic behaviour of marbofloxacin, a new fluoroquinolone antimicrobial agent developed exclusively for veterinary use, was studied in mature horses (n = 5) after single-dose i.v. and i.m. administrations of 2 mg/kg bwt. Drug concentrations in plasma were determined by high performance liquid chromatography (HPLC) and data obtained were subjected to compartmental and noncompartmental kinetic analysis. This compound presents a relatively high volume of distribution (V(SS) = 1.17 +/- 0.18 l/kg), which suggests good tissue penetration, and a total body clearance (Cl) of 0.19 +/- 0.042 l/kgh, which is related to a long elimination half-life (t(1/2beta) = 4.74 +/- 0.8 h and 5.47 +/- 1.33 h i.v. and i.m. respectively). Marbofloxacin was rapidly absorbed after i.m. administration (MAT = 33.8 +/- 14.2 min) and presented high bioavailability (F = 87.9 +/- 6.0%). Pharmacokinetic parameters are not significantly different between both routes of administration (P>0.05). After marbofloxacin i.m. administration, no adverse reactions at the site of injection were observed. Serum CK activity levels 12 h after administration increased over 8-fold (range 3-15) compared with pre-injection levels, but this activity decreased to 3-fold during the 24 h follow-up period. Based on the value of surrogate markers to predict clinical success, Cmax/MIC ratio or AUC/MIC ratio, single daily marbofloxacin dose of 2 mg/kg bwt may not be effective in treating infections in horses caused by pathogens with an MIC > or = 0.25 microg/ml. However, if we use a classical antimicrobial efficacy criteria, marbofloxacin can reach a high plasma peak concentration and maintain concentrations higher than MICs determined for marbofloxacin against most gram-negative veterinary pathogens throughout the administration period. Taking into account the fact that fluoroquinolones are considered to have a concentration-dependent effect and a long postantibiotic effect against gram-negative bacteria, a dose of 2 mg/kg bwt every 24 h could be adequate for marbofloxacin in horses.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0425-1644
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
360-5
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12117107-Absorption,
pubmed-meshheading:12117107-Animals,
pubmed-meshheading:12117107-Anti-Infective Agents,
pubmed-meshheading:12117107-Bacteria,
pubmed-meshheading:12117107-Bacterial Infections,
pubmed-meshheading:12117107-Biological Availability,
pubmed-meshheading:12117107-Chromatography, High Pressure Liquid,
pubmed-meshheading:12117107-Colony Count, Microbial,
pubmed-meshheading:12117107-Dose-Response Relationship, Drug,
pubmed-meshheading:12117107-Female,
pubmed-meshheading:12117107-Fluoroquinolones,
pubmed-meshheading:12117107-Horse Diseases,
pubmed-meshheading:12117107-Horses,
pubmed-meshheading:12117107-Injections, Intramuscular,
pubmed-meshheading:12117107-Injections, Intravenous,
pubmed-meshheading:12117107-Male,
pubmed-meshheading:12117107-Metabolic Clearance Rate,
pubmed-meshheading:12117107-Quinolones,
pubmed-meshheading:12117107-Reference Values,
pubmed-meshheading:12117107-Tissue Distribution,
pubmed-meshheading:12117107-Treatment Outcome
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| pubmed:year |
2002
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| pubmed:articleTitle |
Pharmacokinetics of marbofloxacin in mature horses after single intravenous and intramuscular administration.
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| pubmed:affiliation |
Facultad de Veterinaria, Universidad Complutense de Madrid, Spain.
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| pubmed:publicationType |
Journal Article
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