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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-12
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pubmed:abstractText |
Galectin-9 expression was examined in 6 human melanoma cell lines. Among them, MM-BP proliferated with colony formation, but MM-RU failed. RT-PCR analysis revealed evident expression of galectin-9 mRNA in MM-BP but not in MM-RU. MM-BP expressed galectin-9 protein both on the surface and in the cytoplasm, whereas MM-RU expressed it only weakly in the cytoplasm. Exogenous galectin-9 induced in vitro both cell aggregation and apoptosis of MM-RU proliferating without colony formation. Association of galectin-9 expression in melanoma cells with prognosis of the patients bearing melanocytic tumors was further examined. Galectin-9 protein was strongly and homogeneously expressed in melanocytic nevi, but down-regulated in melanoma cells especially in metastatic lesions. High galectin-9 expression was inversely correlated with the progression of this disease, suggesting that high galectin-9 expression in primary melanoma lesions links to a better prognosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
809-16
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:12115481-Annexin A5,
pubmed-meshheading:12115481-Apoptosis,
pubmed-meshheading:12115481-Blotting, Western,
pubmed-meshheading:12115481-Cell Aggregation,
pubmed-meshheading:12115481-DNA Primers,
pubmed-meshheading:12115481-Disease-Free Survival,
pubmed-meshheading:12115481-Flow Cytometry,
pubmed-meshheading:12115481-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:12115481-Galectins,
pubmed-meshheading:12115481-Humans,
pubmed-meshheading:12115481-Lectins,
pubmed-meshheading:12115481-Melanoma,
pubmed-meshheading:12115481-Nevus, Pigmented,
pubmed-meshheading:12115481-Prognosis,
pubmed-meshheading:12115481-RNA, Messenger,
pubmed-meshheading:12115481-RNA, Neoplasm,
pubmed-meshheading:12115481-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12115481-Skin Neoplasms,
pubmed-meshheading:12115481-Survival Rate,
pubmed-meshheading:12115481-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance.
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pubmed:affiliation |
Department of Dermatology, Kumamoto University Medical School, Kumamoto, Japan. toshiro@kaiju.medic.kumamoto-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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