12115244

Source:http://linkedlifedata.com/resource/pubmed/id/12115244

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0084795, umls-concept:C0086418, umls-concept:C0185117, umls-concept:C0542341, umls-concept:C0936012, umls-concept:C1704711, umls-concept:C2911684
pubmed:issue	5
pubmed:dateCreated	2002-7-12
pubmed:abstractText	The zinc-finger protein tristetraprolin (TTP) has been demonstrated to regulate tumor necrosis factor alpha (TNFalpha) messenger RNA (mRNA) instability in murine macrophages. We sought to develop a model system to characterize the effects of human TTP (hTTP) on TNFalpha 3'-untranslated region (3'-UTR)-mediated expression. We also generated a specific polyclonal antibody against hTTP that enabled the examination of the subcellular distribution of hTTP and its RNA binding in vivo.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01-AI-34928, http://linkedlifedata.com/resource/pubmed/grant/T32 CA-77907
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370605
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Luciferases, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Tristetraprolin, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/ZFP36 protein, human
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0004-3591
pubmed:author	pubmed-author:BrooksSeth ASA, pubmed-author:ConnollyJohn EJE, pubmed-author:DiegelRoger JRJ, pubmed-author:FavaRoy ARA, pubmed-author:RigbyWilliam F CWF
pubmed:issnType	Print
pubmed:volume	46
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1362-70
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:12115244-3' Untranslated Regions, pubmed-meshheading:12115244-Antibody Specificity, pubmed-meshheading:12115244-Arthritis, Rheumatoid, pubmed-meshheading:12115244-Base Sequence, pubmed-meshheading:12115244-Cell Line, pubmed-meshheading:12115244-DNA-Binding Proteins, pubmed-meshheading:12115244-Gene Expression, pubmed-meshheading:12115244-Humans, pubmed-meshheading:12115244-Immediate-Early Proteins, pubmed-meshheading:12115244-Kidney, pubmed-meshheading:12115244-Luciferases, pubmed-meshheading:12115244-Molecular Sequence Data, pubmed-meshheading:12115244-Myeloid Cells, pubmed-meshheading:12115244-RNA, Messenger, pubmed-meshheading:12115244-RNA Processing, Post-Transcriptional, pubmed-meshheading:12115244-Transfection, pubmed-meshheading:12115244-Tristetraprolin, pubmed-meshheading:12115244-Tumor Necrosis Factor-alpha
pubmed:year	2002
pubmed:articleTitle	Analysis of the function, expression, and subcellular distribution of human tristetraprolin.
pubmed:affiliation	Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't