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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-12
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pubmed:abstractText |
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a hyperplastic synovial tissue, inflammatory infiltrates, and a progressive destruction of cartilage and bone. FLICE-inhibitory protein (FLIP) prevents the association of caspase 8 with FADD and thus exerts an antiapoptotic effect through inhibition of Fas-mediated apoptosis. We undertook this study to examine the expression of FLIP in RA, osteoarthritic (OA), and normal synovial tissues.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1512-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12115181-Arthritis, Rheumatoid,
pubmed-meshheading:12115181-Bone and Bones,
pubmed-meshheading:12115181-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:12115181-Carrier Proteins,
pubmed-meshheading:12115181-Cartilage,
pubmed-meshheading:12115181-Cells, Cultured,
pubmed-meshheading:12115181-Fibroblasts,
pubmed-meshheading:12115181-Gene Expression Regulation,
pubmed-meshheading:12115181-Humans,
pubmed-meshheading:12115181-Immunohistochemistry,
pubmed-meshheading:12115181-In Situ Hybridization,
pubmed-meshheading:12115181-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12115181-Osteoarthritis,
pubmed-meshheading:12115181-Polymerase Chain Reaction,
pubmed-meshheading:12115181-RNA, Messenger,
pubmed-meshheading:12115181-Synovial Membrane
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pubmed:year |
2002
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pubmed:articleTitle |
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis.
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pubmed:affiliation |
Center of Experimental Rheumatology, WHO Collaborating Center for Molecular Biology, University Hospital of Zurich, Gloriastrasse 25, CH-8091 Zurich, Switzerland. joerg.schedel@klinik.uni-regensburg.de
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pubmed:publicationType |
Journal Article
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