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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5579
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pubmed:dateCreated |
2002-7-12
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pubmed:abstractText |
Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
297
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12114623-Animals,
pubmed-meshheading:12114623-Body Weight,
pubmed-meshheading:12114623-Crosses, Genetic,
pubmed-meshheading:12114623-Down-Regulation,
pubmed-meshheading:12114623-Eating,
pubmed-meshheading:12114623-Energy Metabolism,
pubmed-meshheading:12114623-Female,
pubmed-meshheading:12114623-Gene Expression,
pubmed-meshheading:12114623-Gene Expression Profiling,
pubmed-meshheading:12114623-Leptin,
pubmed-meshheading:12114623-Lipid Metabolism,
pubmed-meshheading:12114623-Lipids,
pubmed-meshheading:12114623-Lipoproteins, VLDL,
pubmed-meshheading:12114623-Liver,
pubmed-meshheading:12114623-Male,
pubmed-meshheading:12114623-Mice,
pubmed-meshheading:12114623-Mice, Obese,
pubmed-meshheading:12114623-Microsomes, Liver,
pubmed-meshheading:12114623-Mutation,
pubmed-meshheading:12114623-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12114623-Oxygen Consumption,
pubmed-meshheading:12114623-RNA, Messenger,
pubmed-meshheading:12114623-Stearoyl-CoA Desaturase,
pubmed-meshheading:12114623-Vacuoles,
pubmed-meshheading:12114623-Weight Loss
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pubmed:year |
2002
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pubmed:articleTitle |
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
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pubmed:affiliation |
Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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