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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-7-12
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pubmed:abstractText |
Bradykinin (BK) is a potent dilator of the perinatal pulmonary circulation. We investigated segmental differences in BK-induced dilation in newborn pig large conducting pulmonary artery and vein rings and in pressurized pulmonary resistance arteries (PRA). In conducting pulmonary arteries and veins, BK-induced relaxation is abolished by endothelial disruption and by inhibition of nitric oxide (NO) synthase with nitro-L-arginine (L-NA). In PRA, two-thirds of the dilation response is L-NA insensitive. Charybdotoxin plus apamin and depolarization with KCl abolish the L-NA-insensitive dilations, findings that implicate the release of endothelium-derived hyperpolarizing factor (EDHF). However, endothelium-disrupted PRA retain the ability to dilate to BK but not to ACh or A-23187. In endothelium-disrupted PRA, dilation was inhibited by charybdotoxin. Thus in PRA, BK elicits dilation by multiple and duplicative signaling pathways. Release of NO and EDHF contributes to the response in endothelium-intact PRA; in endothelium-disrupted PRA, dilation occurs by direct activation of vascular smooth muscle calcium-dependent potassium channels. Redundant signaling pathways mediating pulmonary dilation to BK may be required to assure a smooth transition to extrauterine life.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/endothelium-dependent...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1040-0605
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L373-82
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12114199-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:12114199-Animals,
pubmed-meshheading:12114199-Animals, Newborn,
pubmed-meshheading:12114199-Biological Factors,
pubmed-meshheading:12114199-Blood Vessels,
pubmed-meshheading:12114199-Bradykinin,
pubmed-meshheading:12114199-Cytochrome P-450 Enzyme System,
pubmed-meshheading:12114199-Endothelium, Vascular,
pubmed-meshheading:12114199-Nitric Oxide,
pubmed-meshheading:12114199-Potassium Channels,
pubmed-meshheading:12114199-Prostaglandins,
pubmed-meshheading:12114199-Pulmonary Circulation,
pubmed-meshheading:12114199-Swine,
pubmed-meshheading:12114199-Vascular Resistance,
pubmed-meshheading:12114199-Vasoconstriction,
pubmed-meshheading:12114199-Vasoconstrictor Agents,
pubmed-meshheading:12114199-Vasodilation,
pubmed-meshheading:12114199-Vasodilator Agents
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pubmed:year |
2002
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pubmed:articleTitle |
Mechanisms of bradykinin-mediated dilation in newborn piglet pulmonary conducting and resistance vessels.
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pubmed:affiliation |
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1081, USA. jaschner@wfubmc.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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