Linked Life Data

12114114

Source:http://linkedlifedata.com/resource/pubmed/id/12114114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-7-12
pubmed:abstractText
The skeleton in vertebrates is composed of bone and cartilage, which contains three specific types: osteoblasts and osteoclasts in bone and chondrocytes in cartilage. Like other cell types in the body, skeletal cell differentiation is controlled by multiple transcription factors at various stages of their development. Cbfa1 and Osx, a newly identified zinc-finger containing protein, are osteoblast-specific transcription factors. Loss of function of either one of them leads to absence of bone in mammals. Here, we discuss transcription factors involved in controlling the differentiation of osteoclasts, such as Pu.1 and nuclear factor (NF)-kappaB, and chondrocytes, such as Sox proteins. Finally, recent progress in identifying mutations in transcription factors affecting skeletal patterning and development is also described.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1471-4914
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Transcription factors in bone: developmental and pathological aspects.
pubmed:affiliation
Dept of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, S930, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't