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pubmed-article:12113825pubmed:abstractTextA total of 24 aryl-substituted analogues of nicotine (1a) and two related series of nicotinic ligands, aminomethylpyridines 3 and ether analogues 8, were examined to determine if they bind at alpha4beta2 nACh receptors in a common manner. A modest correlation (r=0.785) was found between the affinities of the nicotine analogues and derivatives of 3, but little correlation (r=0.348) was found with analogues 8. However, a modest correlation (r=0.742) exists between the binding of analogues 3 and 8. It seems that 1-series and 8-series compounds bind differently but that the 3-series compounds share some intermediate binding similarity with both.lld:pubmed
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pubmed-article:12113825pubmed:articleTitleA comparison of the binding of three series of nicotinic ligands.lld:pubmed
pubmed-article:12113825pubmed:affiliationDepartment of Medicinal Chemistry, School of Pharmacy, Box 980540, Virginia Commonwealth University, Richmond 23298, USA.lld:pubmed
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