|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2002-7-12
|
|
pubmed:abstractText |
A total of 24 aryl-substituted analogues of nicotine (1a) and two related series of nicotinic ligands, aminomethylpyridines 3 and ether analogues 8, were examined to determine if they bind at alpha4beta2 nACh receptors in a common manner. A modest correlation (r=0.785) was found between the affinities of the nicotine analogues and derivatives of 3, but little correlation (r=0.348) was found with analogues 8. However, a modest correlation (r=0.742) exists between the binding of analogues 3 and 8. It seems that 1-series and 8-series compounds bind differently but that the 3-series compounds share some intermediate binding similarity with both.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1989-92
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12113825-Animals,
pubmed-meshheading:12113825-Brain,
pubmed-meshheading:12113825-Chemistry, Physical,
pubmed-meshheading:12113825-Ether, Ethyl,
pubmed-meshheading:12113825-Isoquinolines,
pubmed-meshheading:12113825-Kinetics,
pubmed-meshheading:12113825-Ligands,
pubmed-meshheading:12113825-Nicotine,
pubmed-meshheading:12113825-Physicochemical Phenomena,
pubmed-meshheading:12113825-Protein Binding,
pubmed-meshheading:12113825-Pyridines,
pubmed-meshheading:12113825-Radioligand Assay,
pubmed-meshheading:12113825-Rats,
pubmed-meshheading:12113825-Receptors, Nicotinic,
pubmed-meshheading:12113825-Statistics as Topic,
pubmed-meshheading:12113825-Stereoisomerism,
pubmed-meshheading:12113825-Structure-Activity Relationship
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
A comparison of the binding of three series of nicotinic ligands.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Box 980540, Virginia Commonwealth University, Richmond 23298, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
