Source:http://linkedlifedata.com/resource/pubmed/id/12112647
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-7-11
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pubmed:abstractText |
Background: No effective long-term treatment is available for rheumatoid arthritis. Recent advances in gene therapy and cell therapy have demonstrated efficiency in collagen-induced arthritis (CIA). Interleukin-4 (IL-4) is already known to be efficient in CIA in systemic injection or administered by gene therapy. This study was designed to evaluate the effect of a non-viral gene therapy of CIA, involving injection of syngeneic fibroblasts transfected with a plasmid encoding for IL-4.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1099-498X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12112647-Animals,
pubmed-meshheading:12112647-Arthritis, Experimental,
pubmed-meshheading:12112647-CHO Cells,
pubmed-meshheading:12112647-Cell Division,
pubmed-meshheading:12112647-Cell Line, Transformed,
pubmed-meshheading:12112647-Cricetinae,
pubmed-meshheading:12112647-Fibroblasts,
pubmed-meshheading:12112647-Gene Therapy,
pubmed-meshheading:12112647-Genetic Vectors,
pubmed-meshheading:12112647-Interleukin-4,
pubmed-meshheading:12112647-Male,
pubmed-meshheading:12112647-Mice,
pubmed-meshheading:12112647-Mice, Inbred DBA,
pubmed-meshheading:12112647-Plasmids,
pubmed-meshheading:12112647-T-Lymphocytes
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pubmed:articleTitle |
Syngeneic fibroblasts transfected with a plasmid encoding interleukin-4 as non-viral vectors for anti-inflammatory gene therapy in collagen-induced arthritis.
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pubmed:affiliation |
UPRES EA-3408, Léonard de Vinci Medical School and Department of Rheumatology (Avicenne Hospital, Bobigny, AP-HP), University of Paris 13, Paris, France. bessis@smbh.univ-paris13.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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