Source:http://linkedlifedata.com/resource/pubmed/id/12111596
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-7-11
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| pubmed:abstractText |
From 1991 to 2000, 125 sporadic cases of Klebsiella oxytoca bacteremia were analyzed retrospectively to review clinical features and to identify the risk factors associated with resistance to extended-spectrum cephalosporins and fatal outcome. Bacteremia was acquired nosocomially in 52% of the patients. Almost all patients (97%) had an underlying disease, with biliary and pancreatic disease occurring most frequently (55%). The biliary tract was the most common site of infection (44%). Resistance to extended-spectrum cephalosporins was identified in 22 of the 125 (18%) Klebsiella oxytoca blood isolates and resistance to ciprofloxacin in 9 (7%). Only previous antibiotic therapy was strongly associated with resistance to extended-spectrum cephalosporins in patients with Klebsiella oxytoca bacteremia ( P=0.009). The mortality rate was 24% and was higher in patients infected with isolates resistant to extended-spectrum cephalosporins (41% vs. 20%; P=0.04). In multivariate analysis, fatal outcome was independently associated with septic shock, deteriorated mental status, polymicrobial bacteremia, and solid tumor. Surgical therapy had a protective effect (OR, 0.06; 95% CI, 0.005-0.7; P=0.03). In conclusion, Klebsiella oxytoca bacteremia was most commonly associated with biliary tract infection. Previous antibiotic therapy was strongly associated with resistance to extended-spectrum cephalosporins in patients with Klebsiella oxytoca bacteremia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0934-9723
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
419-26
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12111596-Adolescent,
pubmed-meshheading:12111596-Adult,
pubmed-meshheading:12111596-Aged,
pubmed-meshheading:12111596-Aged, 80 and over,
pubmed-meshheading:12111596-Anti-Bacterial Agents,
pubmed-meshheading:12111596-Bacteremia,
pubmed-meshheading:12111596-Cephalosporins,
pubmed-meshheading:12111596-Child,
pubmed-meshheading:12111596-Child, Preschool,
pubmed-meshheading:12111596-Drug Resistance, Bacterial,
pubmed-meshheading:12111596-Female,
pubmed-meshheading:12111596-Humans,
pubmed-meshheading:12111596-Infant,
pubmed-meshheading:12111596-Infant, Newborn,
pubmed-meshheading:12111596-Klebsiella,
pubmed-meshheading:12111596-Klebsiella Infections,
pubmed-meshheading:12111596-Male,
pubmed-meshheading:12111596-Microbial Sensitivity Tests,
pubmed-meshheading:12111596-Middle Aged,
pubmed-meshheading:12111596-Retrospective Studies,
pubmed-meshheading:12111596-Risk Factors,
pubmed-meshheading:12111596-Treatment Outcome
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Retrospective analysis of clinical and microbiological aspects of Klebsiella oxytoca bacteremia over a 10-year period.
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| pubmed:affiliation |
Division of Infectious Diseases, Asan Medical Center, and Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Seoul, Korea.
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| pubmed:publicationType |
Journal Article
|