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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7-8
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pubmed:dateCreated |
2002-7-11
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pubmed:abstractText |
Fatal familial insomnia (FFI) is a rare hereditary human prion disease with unique clinical features including progressive sleep impairment and autonomic dysfunction. The serotonergic system is considered to be involved in the regulation of the sleep-wake cycle. In this study we demonstrate a reduced availability of serotonin transporters of 57% and 73% respectively in a thalamus-hypothalamus region of two FFI patients examined with beta-CIT SPECT as compared to age-expected control values.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0300-9564
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1105-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12111447-Adult,
pubmed-meshheading:12111447-Carrier Proteins,
pubmed-meshheading:12111447-Cerebellum,
pubmed-meshheading:12111447-Cocaine,
pubmed-meshheading:12111447-Corpus Striatum,
pubmed-meshheading:12111447-Humans,
pubmed-meshheading:12111447-Hypothalamus,
pubmed-meshheading:12111447-Male,
pubmed-meshheading:12111447-Membrane Glycoproteins,
pubmed-meshheading:12111447-Membrane Transport Proteins,
pubmed-meshheading:12111447-Nerve Tissue Proteins,
pubmed-meshheading:12111447-Prion Diseases,
pubmed-meshheading:12111447-Radiopharmaceuticals,
pubmed-meshheading:12111447-Reference Values,
pubmed-meshheading:12111447-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:12111447-Thalamus,
pubmed-meshheading:12111447-Tissue Distribution,
pubmed-meshheading:12111447-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2002
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pubmed:articleTitle |
Beta-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia.
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pubmed:affiliation |
Institute of Neurology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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