Source:http://linkedlifedata.com/resource/pubmed/id/12111186
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2002-7-11
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| pubmed:abstractText |
Despite the fact that group A streptococci (GAS) remain susceptible to penicillin V (pen V), an increasing rate of bacteriological treatment failures has occurred. A recent study has suggested that the major variables associated with pen V treatment failures were the number of days ill prior to initiation of treatment (<2 days) and age <6 years. In order to study the link between pen V treatment failures and individual variables, we reviewed the files of all children enrolled in four randomised multicentre trials of oral antibiotic therapy, carried out from 1993 to 1999. A standard protocol and follow-up examination were used in these four studies: cultures were obtained 4 days and 1 month after completion of treatment. Total DNA restriction fragment length polymorphism was used to compare pre- and post-treatment GAS isolates. We enrolled 1560 children aged 3 to 12 years, 685 received a 10 day pen V regimen (45 mg/kg per day divided into three doses/day), among them 536 were assessable for bacteriological efficacy at the first and second follow-up visit. We found the only variable associated with penicillin treatment failure was the age of the child when infected. The rate of failure was statistically more important for children younger than 6 years (35.5%, 95% CI 29.9--41.1) than for older children (21.9%, 95% CI 16.9-26.9). CONCLUSION: in this study only young age (<6 years) increases penicillin V treatment failures for group A streptococcal tonsillopharyngitis. This may lead to different antibiotic regimens and follow-up modalities for these targeted patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0340-6199
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
161
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
365-7
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12111186-Adolescent,
pubmed-meshheading:12111186-Chi-Square Distribution,
pubmed-meshheading:12111186-Child,
pubmed-meshheading:12111186-Child, Preschool,
pubmed-meshheading:12111186-Confidence Intervals,
pubmed-meshheading:12111186-Drug Administration Schedule,
pubmed-meshheading:12111186-Drug Resistance, Microbial,
pubmed-meshheading:12111186-Female,
pubmed-meshheading:12111186-Follow-Up Studies,
pubmed-meshheading:12111186-France,
pubmed-meshheading:12111186-Humans,
pubmed-meshheading:12111186-Male,
pubmed-meshheading:12111186-Microbial Sensitivity Tests,
pubmed-meshheading:12111186-Penicillin V,
pubmed-meshheading:12111186-Pharyngitis,
pubmed-meshheading:12111186-Probability,
pubmed-meshheading:12111186-Randomized Controlled Trials as Topic,
pubmed-meshheading:12111186-Retrospective Studies,
pubmed-meshheading:12111186-Streptococcal Infections,
pubmed-meshheading:12111186-Streptococcus pyogenes,
pubmed-meshheading:12111186-Tonsillitis,
pubmed-meshheading:12111186-Treatment Outcome
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Variables influencing bacteriological outcome in patients with streptococcal tonsillopharyngitis treated with penicillin V.
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| pubmed:affiliation |
Department of Paediatrics, Créteil Hospital, Paris, France. Activ@wanadoo.fr
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| pubmed:publicationType |
Journal Article,
Comparative Study
|