Linked Life Data

12111003

Source:http://linkedlifedata.com/resource/pubmed/id/12111003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-7-11
pubmed:abstractText
In a previous report, we demonstrated that the exposure of cultured mouse cerebellar granule cells to permethrin, a type I pyrethroid insecticide, repressed the induction of activity-dependent c- fos and brain-derived neurotrophic factor (BDNF) gene expression, accompanying a decrease in Ca(2+) influx into neurons. In addition, it has been suggested that some pyrethroids, including permethrin, are endocrine-modulating chemicals and accumulate in human breast milk. In this study, therefore, we investigated whether lactational exposure of newborn mice to permethrin influenced c- fos, BDNF and beta-actin gene expression in the developing neonatal cerebellum. In the cerebella of control neonates, c- fos mRNA expression was characterized by a significant increase in postnatal weeks 2 and 3, followed by a marked decrease. In the cerebella of permethrin-treated neonates, the expression of c- fos mRNA was dose-dependently repressed by cis-permethrin more effectively than by trans-permethrin at postnatal week 3, without alterations in the body or cerebellum weights of neonates. In the fourth and fifth week, however, c- fos mRNA expression had decreased to the same level as that in the control and permethrin-treated neonates. A decrease in BDNF mRNA expression tended to be observed in the cerebella of newborn mice on exposure to permethrin. Thus, our results indicate that the activity-dependent gene expressions in cerebellar neuronal cells can be repressed by permethrin both in vitro and in vivo, and suggest that lactational exposure to pyrethroids might affect the postnatal development of the mammalian brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
392-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Neonatal exposure of newborn mice to pyrethroid (permethrin) represses activity-dependent c-fos mRNA expression in cerebellum.
pubmed:affiliation
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Shibuya 3-13-11, Tokyo 150-0002, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't