Source:http://linkedlifedata.com/resource/pubmed/id/12109032
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-7-11
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pubmed:abstractText |
The cellular joint infiltrate in rheumatoid arthritis patients is rich in CD4-positive T-helper lymphocytes and macrophages, rendering anti-CD4 monoclonal antibodies (mAbs) suitable for specific immunoscintigraphy of human/experimental arthritis. Following intravenous injection, however, mAbs are present both in the free form and bound to CD4-positive, circulating monocytes and T-cells. Thus, the present study aimed at analyzing the relative contribution of the free and the cell-bound component to the imaging of inflamed joints in experimental adjuvant arthritis (AA).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0029-5566
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-34
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pubmed:dateRevised |
2007-1-12
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pubmed:meshHeading |
pubmed-meshheading:12109032-Animals,
pubmed-meshheading:12109032-Antibodies, Monoclonal,
pubmed-meshheading:12109032-Antigens, CD4,
pubmed-meshheading:12109032-Arthritis, Experimental,
pubmed-meshheading:12109032-Female,
pubmed-meshheading:12109032-Inflammation,
pubmed-meshheading:12109032-Joint Diseases,
pubmed-meshheading:12109032-Macrophages,
pubmed-meshheading:12109032-Radioimmunodetection,
pubmed-meshheading:12109032-Rats,
pubmed-meshheading:12109032-Rats, Inbred Lew,
pubmed-meshheading:12109032-Technetium,
pubmed-meshheading:12109032-Tissue Distribution
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pubmed:year |
2002
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pubmed:articleTitle |
Minimal contribution of cell-bound antibodies to the immunoscintigraphy of inflamed joints with 99mTc-anti-CD4 monoclonal antibodies.
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pubmed:affiliation |
Experimental Rheumatology Unit, Friedrich Schiller University of Jena. Raimund.W.Kinne@rz.uni-jena.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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