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rdf:type |
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lifeskim:mentions |
umls-concept:C0003765,
umls-concept:C0010654,
umls-concept:C0021655,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0033085,
umls-concept:C0034818,
umls-concept:C0205082,
umls-concept:C0441471,
umls-concept:C0597357,
umls-concept:C1710082
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pubmed:issue |
5
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pubmed:dateCreated |
2002-7-10
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pubmed:abstractText |
We examined the properties of a mutant insulin receptor (IR) with an Arg(252) to Cys (IR(R252C)) substitution in the alpha-subunit originally identified in a patient with extreme insulin resistance and acanthosis nigricans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
657-67
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12107746-Acanthosis Nigricans,
pubmed-meshheading:12107746-Adult,
pubmed-meshheading:12107746-Amino Acid Substitution,
pubmed-meshheading:12107746-Animals,
pubmed-meshheading:12107746-Arginine,
pubmed-meshheading:12107746-CHO Cells,
pubmed-meshheading:12107746-Cricetinae,
pubmed-meshheading:12107746-Cysteine,
pubmed-meshheading:12107746-DNA,
pubmed-meshheading:12107746-Humans,
pubmed-meshheading:12107746-Insulin,
pubmed-meshheading:12107746-Insulin Resistance,
pubmed-meshheading:12107746-Male,
pubmed-meshheading:12107746-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12107746-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12107746-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12107746-Mutation,
pubmed-meshheading:12107746-Phosphorylation,
pubmed-meshheading:12107746-Protein Subunits,
pubmed-meshheading:12107746-Protein Transport,
pubmed-meshheading:12107746-Receptor, Insulin,
pubmed-meshheading:12107746-Recombinant Proteins,
pubmed-meshheading:12107746-Signal Transduction,
pubmed-meshheading:12107746-Thymidine,
pubmed-meshheading:12107746-Transfection
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pubmed:year |
2002
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pubmed:articleTitle |
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
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pubmed:affiliation |
Department of Morphology, University of Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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