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pubmed-article:12107586pubmed:dateCreated2002-7-10lld:pubmed
pubmed-article:12107586pubmed:abstractTextVessel oxygen saturation can be determined with MR oximetry using an in vivo measurement of signal decay (T2) and the calibration curve relating T2 to blood oxygen saturation (%HbO(2)), where: 1/T2=1/T2O+K (1-%HbO(2)/100)(2) and K is a constant parameter which correlates with measured fibrinogen levels. The ability to noninvasively measure %HbO(2) in cardiac chambers and vessels has enormous potential in children with congenital heart disease (CHD). Objective: The purpose of the study was to prospectively characterize the T2-%HbO(2) relationship in infants where T2-%HbO(2) is the relationship between T2 and %HbO(2) (blood oxygen saturation) expressed by the equation given above, and to determine whether adult values for K and T2O (where T2O is the T2 of fully oxygenated blood) can be extrapolated to pediatric patients with CHD. A second objective was to apply this method to calculate the %HbO(2) in vivo using MR imaging in infants with CHD.lld:pubmed
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pubmed-article:12107586pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12107586pubmed:year2002lld:pubmed
pubmed-article:12107586pubmed:articleTitleMRI-based blood oxygen saturation measurements in infants and children with congenital heart disease.lld:pubmed
pubmed-article:12107586pubmed:affiliationDepartment of Paediatrics and Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. lynne_nield@hotmail.comlld:pubmed
pubmed-article:12107586pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:12107586pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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