| pubmed-article:12106590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0532903 | lld:lifeskim |
| pubmed-article:12106590 | lifeskim:mentions | umls-concept:C0532905 | lld:lifeskim |
| pubmed-article:12106590 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12106590 | pubmed:dateCreated | 2002-7-10 | lld:pubmed |
| pubmed-article:12106590 | pubmed:abstractText | alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were investigated in (30-35 weeks old) spontaneously hypertensive rats (SHR) with established hypertension and age-matched normotensive Wistar-Kyoto (WKY) rats in vitro. In addition, we studied the vascular effects of another structurally related tetrapeptide, beta-lactorphin (Tyr-Leu-Leu-Phe), which originates from milk protein beta-lactoglobulin. Endothelium-dependent relaxation to acetylcholine (ACh) was reduced in mesenteric arterial preparations of SHR as compared to those of WKY. In SHR, the ACh-induced relaxation was augmented by alpha-lactorphin or beta-lactorphin. The role of nitric oxide (NO) is suggested, since this improvement was abolished by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). Simultaneous potassium channel inhibitor tetraethylammonium (TEA) elicited no additional effect on the ACh-induced relaxation. The cyclooxygenase inhibitor diclofenac did not attenuate the augmented ACh relaxation induced by alpha-lactorphin or beta-lactorphin, suggesting that endothelial vasodilatory prostanoids were not involved in the effect of the tetrapeptides. Endothelium-independent relaxation to the NO donor sodium nitroprusside (SNP) was augmented in mesenteric arterial preparations of SHR by simultaneous beta-lactorphin. The tetrapeptides did not alter vascular responses in mesenteric arteries from WKY. In conclusion, both alpha-lactorphin and beta-lactorphin improved vascular relaxation in adult SHR in vitro. The beneficial effect of alpha-lactorphin was directed towards endothelial function, whereas beta-lactorphin also enhanced endothelium-independent relaxation. | lld:pubmed |
| pubmed-article:12106590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12106590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12106590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12106590 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12106590 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:VapaataloHeik... | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:KorpelaRiitta... | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:SipolaMarikaM | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:FinckenbergPi... | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:NurminenMarja... | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:Pihlanto-Lepp... | lld:pubmed |
| pubmed-article:12106590 | pubmed:author | pubmed-author:KorhonenHannu... | lld:pubmed |
| pubmed-article:12106590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12106590 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:12106590 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:12106590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12106590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12106590 | pubmed:pagination | 1245-53 | lld:pubmed |
| pubmed-article:12106590 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12106590 | pubmed:meshHeading | pubmed-meshheading:12106590... | lld:pubmed |
| pubmed-article:12106590 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12106590 | pubmed:articleTitle | Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats. | lld:pubmed |
| pubmed-article:12106590 | pubmed:affiliation | Institute of Biomedicine, Pharmacology, BIOMEDICUM HELSINKI, P.O. Box 63, FIN-00014 University of Helsinki, Finland. marika.sipola@helsinki.fi | lld:pubmed |
| pubmed-article:12106590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12106590 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12106590 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12106590 | lld:pubmed |
