|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2002-7-10
|
|
pubmed:abstractText |
Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional' suppressor cells and other cytokine-producing CD4+ and CD8+ T-cell subsets mediate this protective function. Evidence will be reviewed that T cells primed with transforming growth factor (TGF)-beta expand rapidly following restimulation. Certain CD4+ T cells become contact-dependent suppressor cells and other CD4+ and CD8+ cells become cytokine-producing regulatory cells. This effect is dependent upon a sufficient amount of IL-2 in the microenvironment to overcome the suppressive effects of TGF-beta. The adoptive transfer of these suppressor cells generated ex vivo can protect mice from developing chronic graft-versus-host disease with a lupus-like syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-beta have the potential to be used as a therapy for patients with systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10490963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10605010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10628770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10784608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10837065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10878341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10887343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10917889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-10940900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11006017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11009098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-1101469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11046008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11067871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11298337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11298351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11298829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11313392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11359436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11390435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11390436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11390437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11390478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11418648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11441082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11466326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11466340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11514601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11526392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11535631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11564443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-11591746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-1386312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-3871469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-6216769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-6233372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7515921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7520605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7590822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7608539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7636184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7912547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-7964469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-8094734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-8144953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-8690806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9218758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9338786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9498764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9498800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9536936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9597127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9637480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9743345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9892606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12106494-9914214
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1465-9905
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
241-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12106494-Humans,
pubmed-meshheading:12106494-Animals,
pubmed-meshheading:12106494-Lupus Erythematosus, Systemic,
pubmed-meshheading:12106494-Immunotherapy,
pubmed-meshheading:12106494-Lymphocyte Activation,
pubmed-meshheading:12106494-Cell Transplantation,
pubmed-meshheading:12106494-T-Lymphocyte Subsets,
pubmed-meshheading:12106494-T-Lymphocytes, Regulatory,
pubmed-meshheading:12106494-Interleukin-2,
pubmed-meshheading:12106494-Receptors, Interleukin-2,
pubmed-meshheading:12106494-Transforming Growth Factor beta,
pubmed-meshheading:12106494-CD4-Positive T-Lymphocytes
|
