rdf:type |
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lifeskim:mentions |
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pubmed:issue |
35
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pubmed:dateCreated |
2002-8-30
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pubmed:abstractText |
Vitamin E is a lipophilic anti-oxidant that can prevent the oxidative damage of atherogenic lipoproteins. However, human trials with vitamin E have been disappointing, perhaps related to ineffective levels of vitamin E in atherogenic apoB-containing lipoproteins. Phospholipid transfer protein (PLTP) promotes vitamin E removal from atherogenic lipoproteins in vitro, and PLTP deficiency has recently been recognized as an anti-atherogenic state. To determine whether PLTP regulates lipoprotein vitamin E content in vivo, we measured alpha-tocopherol content and oxidation parameters of lipoproteins from PLTP-deficient mice in wild type, apoE-deficient, low density lipoprotein (LDL) receptor-deficient, or apoB/cholesteryl ester transfer protein transgenic backgrounds. In all four backgrounds, the vitamin E content of very low density lipoprotein (VLDL) and/or LDL was significantly increased in PLTP-deficient mice, compared with controls with normal plasma PLTP activity. Moreover, PLTP deficiency produced a dramatic delay in generation of conjugated dienes in oxidized apoB-containing lipoproteins as well as markedly lower titers of plasma IgG autoantibodies to oxidized LDL. The addition of purified PLTP to deficient plasma lowered the vitamin E content of VLDL plus LDL and normalized the generation of conjugated dienes. The data show that PLTP regulates the bioavailability of vitamin E in atherogenic lipoproteins and suggest a novel strategy for achieving more effective concentrations of anti-oxidants in lipoproteins, independent of dietary supplementation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ca(2 ) Mg(2 )-ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipid Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:AthiasAnneA,
pubmed-author:DeckertValéerieV,
pubmed-author:DesrumauxCatherineC,
pubmed-author:JiangXian-ChengXC,
pubmed-author:LagrostLaurentL,
pubmed-author:LalanneFlorentF,
pubmed-author:QinShucunS,
pubmed-author:RakS LSL,
pubmed-author:SchneiderMartinaM,
pubmed-author:TallAlan RAR,
pubmed-author:WitztumJoseph LJL
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31850-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12105225-Animals,
pubmed-meshheading:12105225-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:12105225-Carrier Proteins,
pubmed-meshheading:12105225-Cholesterol,
pubmed-meshheading:12105225-Humans,
pubmed-meshheading:12105225-Hyperlipidemias,
pubmed-meshheading:12105225-Immunoglobulin G,
pubmed-meshheading:12105225-Immunoglobulin M,
pubmed-meshheading:12105225-Kinetics,
pubmed-meshheading:12105225-Lipoproteins,
pubmed-meshheading:12105225-Membrane Proteins,
pubmed-meshheading:12105225-Mice,
pubmed-meshheading:12105225-Mice, Knockout,
pubmed-meshheading:12105225-Oxidation-Reduction,
pubmed-meshheading:12105225-Phospholipid Transfer Proteins,
pubmed-meshheading:12105225-Phospholipids,
pubmed-meshheading:12105225-Triglycerides,
pubmed-meshheading:12105225-Vitamin E
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pubmed:year |
2002
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pubmed:articleTitle |
Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E.
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pubmed:affiliation |
Downstate Medical Center, State University of New York, New York, New York 11203, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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