Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2002-7-8
pubmed:abstractText
Intestinal gene regulation involves mechanisms that direct temporal expression along the vertical and horizontal axes of the alimentary tract. Sucrase-isomaltase (SI), the product of an enterocyte-specific gene, exhibits a complex pattern of expression. Generation of transgenic mice with a mutated SI transgene showed involvement of an overlapping CDP (CCAAT displacement protein)-GATA element in colonic repression of SI throughout postnatal intestinal development. We define this element as CRESIP (colon-repressive element of the SI promoter). Cux/CDP interacts with SI and represses SI promoter activity in a CRESIP-dependent manner. Cux/CDP homozygous mutant mice displayed increased expression of SI mRNA during early postnatal development. Our results demonstrate that an intestinal gene can be repressed in the distal gut and identify Cux/CDP as a regulator of this repression during development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-10075672, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-10592259, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-10606245, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-10864926, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-10869351, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11040183, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11042222, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11084046, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11395488, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11403998, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11509674, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11544187, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11729123, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-11739170, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1301999, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1373876, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1378530, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1692546, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1707385, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1764023, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-1821846, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-2759730, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-2897632, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-6352518, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7692743, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7791766, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7799919, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7910552, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7914370, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-7935448, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8006012, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8196661, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8214074, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8330519, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8552090, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8572224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8798433, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-8816446, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9171078, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9252513, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9419421, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9707427, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9727977, http://linkedlifedata.com/resource/pubmed/commentcorrection/12101240-9828099
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5467-78
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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