Linked Life Data

12101023

Source:http://linkedlifedata.com/resource/pubmed/id/12101023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-7-8
pubmed:abstractText
We have used isothermal titration calorimetry (ITC) to study the thermodynamics of Triton X-100 (T(X-100)), deoxycholate and decyl octaethylene glycol (C(10)EO(8)) penetration into bilayers composed of native (ESM) and hydrogenated egg yolk sphingomyelin (DHSM). Light scattering measurements were used to study the point of saturation (R(e,sat)) and the onset of solubilization of membranes by the detergents. We found that DHSM bilayers at 25 degrees C were much more resistant to detergent partitioning (lower K) and gave higher reaction enthalpies (DeltaH) for all three detergents compared to the ESM bilayer system. Because DHSM lacks double bonds (Delta(4trans) and some cis bonds as well), attractive acyl chain interactions are favored in membranes of this lipid class. The high stability and cohesion of DHSM in membranes could be a crucial functional property of this lipid as it is enriched in eye lens membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
1564
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Partitioning of Triton X-100, deoxycholate and C(10)EO(8) into bilayers composed of native and hydrogenated egg yolk sphingomyelin.
pubmed:affiliation
Department of Biochemistry and Pharmacy, Abo Akademi University, P.O. Box 66, FIN 20521 Turku, Finland. follila@abo.fi
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't