Source:http://linkedlifedata.com/resource/pubmed/id/12099906
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2002-7-8
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| pubmed:abstractText |
Central administration of corticotropin-releasing hormone increases anxiety-like behaviour and arousal in rodents, and increased anxiety-like behaviour has been shown in mice overproducing corticotropin-releasing hormone on an elevated plus maze and in a dark-light emergence task. However, evidence is accumulating that measures obtained from different anxiety tasks may reflect different aspects of anxiety-like behaviour in animals. We therefore tested mice overproducing corticotropin-releasing hormone in a battery of paradigms, studying spontaneous behaviour after a mild stressor, tasks of innate anxiety-like behaviour (light-dark box), lick suppression (Vogel conflict), conditioned fear, and forced swimming. Exploratory behaviour was studied in a 16-hole board task. Furthermore, pain threshold, water intake, locomotor activity and sensorimotor learning/co-ordination were tested to control for confounding factors. In line with previous findings, increased anxiety-like behaviour of transgenic mice was observed in the light-dark box paradigm. However, no differences were seen in the conflict paradigm. Conditioned fear was decreased 1 h but not 24 h after conditioning in transgenic mice, and immobility was decreased [corrected] in forced swimming in corticotropin-releasing hormone overexpressors. Locomotor activity in a novel open field and on the hole board was reduced in transgenics. Exploratory behaviour (hole pokes) was reduced during initial exploration of an unfamiliar hole board. Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception. No differences in locomotor activity were seen in a second group of mice, tested in a familiar open field. When these animals were challenged with diazepam, transgenic mice were less susceptible to the sedative effects of the drug on locomotor activity. These data suggest that corticotropin-releasing hormone overproduction leads to specific effects in a subset of anxiety paradigms, and that these transgenic mice suffer from a motor deficit in addition to altered anxiety-like behaviour/arousal.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0953-816X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2007-15
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12099906-Animals,
pubmed-meshheading:12099906-Anti-Anxiety Agents,
pubmed-meshheading:12099906-Anxiety,
pubmed-meshheading:12099906-Behavior, Animal,
pubmed-meshheading:12099906-Brain,
pubmed-meshheading:12099906-Brain Chemistry,
pubmed-meshheading:12099906-Corticotropin-Releasing Hormone,
pubmed-meshheading:12099906-Dark Adaptation,
pubmed-meshheading:12099906-Diazepam,
pubmed-meshheading:12099906-Drinking,
pubmed-meshheading:12099906-Exploratory Behavior,
pubmed-meshheading:12099906-Fear,
pubmed-meshheading:12099906-Genetic Predisposition to Disease,
pubmed-meshheading:12099906-Male,
pubmed-meshheading:12099906-Mice,
pubmed-meshheading:12099906-Mice, Transgenic,
pubmed-meshheading:12099906-Motor Activity,
pubmed-meshheading:12099906-Neurons,
pubmed-meshheading:12099906-Pain Threshold,
pubmed-meshheading:12099906-Photic Stimulation,
pubmed-meshheading:12099906-Reaction Time,
pubmed-meshheading:12099906-Stress, Physiological,
pubmed-meshheading:12099906-Up-Regulation
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effects of transgenic overproduction of CRH on anxiety-like behaviour.
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| pubmed:affiliation |
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, D-80804 Munich, Germany. mm.van_gaalen.pharm@med.vu.nl
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| pubmed:publicationType |
Journal Article
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