Source:http://linkedlifedata.com/resource/pubmed/id/12099367
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-7-8
|
| pubmed:abstractText |
National statistics for patient characteristics and survival of renal transplant recipients positive for hepatitis C virus (HCV+) at the time of renal transplant are presented. A historical cohort analysis of 33479 renal transplant recipients in the United States Renal Data System from 1 July, 1994 to 30 June, 1997 has been carried out. The medical evidence form was also used for additional variables, but because of fewer available values, this was analyzed in a separate model. Outcomes were patient characteristics and survival associated with HCV+. Of 28692 recipients with valid HCV serologies, 1624 were HCV+ at transplant (5.7% prevalence). In logistic regression analysis, HCV+ was associated with African-American race, male gender, cadaveric donor type, increased duration of pre-transplant dialysis, previous transplant, donor HCV+, recipient (but not donor) age, serum albumin, alcohol use, and increased all-cause hospitalizations. Diabetes and IgA nephropathy were less associated with HCV+. Total all-cause, unadjusted mortality was 13.1% in HCV+ vs. 8.5% in HCV- patients (p <0.01 by log rank test). In Cox regression, mortality was higher for HCV+ (adjusted hazard ratio = 1.23, 95% confidence interval = 1.01-1.49, p = 0.04). HCV+ recipients were more likely to be African-American, male, older, and to have received repeat transplants and donor HCV+ transplants. HCV+ recipients also had substantially longer waiting times for transplant. In contrast to recent studies, diabetes did not have an increased association with HCV+, perhaps due to limitations of the database. HCV+ recipients had increased mortality and hospitalization rates compared with other transplant recipients.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1600-6135
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
179-84
|
| pubmed:dateRevised |
2007-2-14
|
| pubmed:meshHeading |
pubmed-meshheading:12099367-Adolescent,
pubmed-meshheading:12099367-Adult,
pubmed-meshheading:12099367-African Americans,
pubmed-meshheading:12099367-Aged,
pubmed-meshheading:12099367-Cadaver,
pubmed-meshheading:12099367-Female,
pubmed-meshheading:12099367-Hepacivirus,
pubmed-meshheading:12099367-Hepatitis C,
pubmed-meshheading:12099367-Humans,
pubmed-meshheading:12099367-Kidney Transplantation,
pubmed-meshheading:12099367-Male,
pubmed-meshheading:12099367-Middle Aged,
pubmed-meshheading:12099367-Models, Statistical,
pubmed-meshheading:12099367-Prevalence,
pubmed-meshheading:12099367-Regression Analysis,
pubmed-meshheading:12099367-Retrospective Studies,
pubmed-meshheading:12099367-Survival Rate,
pubmed-meshheading:12099367-United States
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival.
|
| pubmed:affiliation |
Organ Transplantation Service, Walter Reed Army Medical Center, National Institutes of Health, Bethesda, MD, USA.
|
| pubmed:publicationType |
Journal Article
|