pubmed-article:12098845 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0324306 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0014994 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0020615 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0037549 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0205345 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0006935 | lld:lifeskim |
pubmed-article:12098845 | lifeskim:mentions | umls-concept:C0939975 | lld:lifeskim |
pubmed-article:12098845 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:12098845 | pubmed:dateCreated | 2002-7-8 | lld:pubmed |
pubmed-article:12098845 | pubmed:abstractText | The hypoglycemic effect of oral insulin capsules coated with pH-dependent Eudragit S100 and containing various absorption promoters was studied in hyperglycemic beagle dogs. The absorption enhancers used were bioadhesive polymers, sodium salicylate, and non-ionic surfactants. A comparative study of the bioadhesive polymers, polycarbophil (PC), hydroxypropyl methylcellulose (HPMC), and carbopol 934 in insulin-coated capsules revealed no significant difference between the insulin capsules containing these polymers, giving relative hypoglycemia (RH) values ranging from 4.3 +/- 2.3% to 6.5 +/- 5.1%. It was also found that the method of preparation of the mixture of the bioadhesive polymer with insulin either by physical mixing or freeze-drying did not affect the RH values obtained. Sodium salicylate, when used in insulin enteric-coated capsules (50 mg) mixed with insulin as a physical mixture, or prepared by wet granulation using 10% polyvinyl pyrollidone (PVP), or by freeze-drying, produced RH values ranging from 7.3 +/- 2.9% to 9.4 +/- 3.7%. When sodium salicylate (100 mg) was used with insulin in freeze-dried granules an RH value of 10 +/- 2.6% was produced. As the dose of insulin increased from 6 to 9 U/kg, the area under curve (AUC) of the enteric-coated capsules containing 50 mg sodium salicylate increased from 73.2 +/- 27.8% to 121.4 +/- 102.7% reduction, but the RH did not change significantly. Insulin capsules containing polyoxyethylene-9-lauryl ether (POELE) used in its optimum concentration (2%), found in these experiments, produced RH of 9.5 +/- 6.8% when prepared as granules by wetting with a few drops of absolute alcohol in the presence of PC (50 mg). Insulin capsules containing lower (1%) or higher (3%) concentrations of POELE and prepared with PC, 50 mg by wet granulation produced lower RH of about 6%. The enteric-coated oral insulin capsules containing insulin (6 or 9 U/kg) and sodium salicylate (50 mg) as an absorption promoter, together with the bioadhesive polymer polycarbophil (50 mg), and prepared either by wet granulation using ethanol or by freeze-drying, are the best formulations to be used. They achieved a reduction in plasma glucose levels of about 25-30% and RH of about 10%. Also insulin (9 U/kg) capsules containing 2% POELE produced a 28% reduction in plasma glucose levels and RH of 9.6 +/- 6.8%. | lld:pubmed |
pubmed-article:12098845 | pubmed:language | eng | lld:pubmed |
pubmed-article:12098845 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12098845 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12098845 | pubmed:month | May | lld:pubmed |
pubmed-article:12098845 | pubmed:issn | 0363-9045 | lld:pubmed |
pubmed-article:12098845 | pubmed:author | pubmed-author:HosnyE AEA | lld:pubmed |
pubmed-article:12098845 | pubmed:author | pubmed-author:al-ShoraH IHI | lld:pubmed |
pubmed-article:12098845 | pubmed:author | pubmed-author:ElmazarM M... | lld:pubmed |
pubmed-article:12098845 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12098845 | pubmed:volume | 28 | lld:pubmed |
pubmed-article:12098845 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12098845 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12098845 | pubmed:pagination | 563-70 | lld:pubmed |
pubmed-article:12098845 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:meshHeading | pubmed-meshheading:12098845... | lld:pubmed |
pubmed-article:12098845 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:12098845 | pubmed:articleTitle | Effect of bioadhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether, and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs. | lld:pubmed |
pubmed-article:12098845 | pubmed:affiliation | Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ehosny@ksu.edu.sa | lld:pubmed |
pubmed-article:12098845 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12098845 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:12098845 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |