Source:http://linkedlifedata.com/resource/pubmed/id/12098845
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2002-7-8
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| pubmed:abstractText |
The hypoglycemic effect of oral insulin capsules coated with pH-dependent Eudragit S100 and containing various absorption promoters was studied in hyperglycemic beagle dogs. The absorption enhancers used were bioadhesive polymers, sodium salicylate, and non-ionic surfactants. A comparative study of the bioadhesive polymers, polycarbophil (PC), hydroxypropyl methylcellulose (HPMC), and carbopol 934 in insulin-coated capsules revealed no significant difference between the insulin capsules containing these polymers, giving relative hypoglycemia (RH) values ranging from 4.3 +/- 2.3% to 6.5 +/- 5.1%. It was also found that the method of preparation of the mixture of the bioadhesive polymer with insulin either by physical mixing or freeze-drying did not affect the RH values obtained. Sodium salicylate, when used in insulin enteric-coated capsules (50 mg) mixed with insulin as a physical mixture, or prepared by wet granulation using 10% polyvinyl pyrollidone (PVP), or by freeze-drying, produced RH values ranging from 7.3 +/- 2.9% to 9.4 +/- 3.7%. When sodium salicylate (100 mg) was used with insulin in freeze-dried granules an RH value of 10 +/- 2.6% was produced. As the dose of insulin increased from 6 to 9 U/kg, the area under curve (AUC) of the enteric-coated capsules containing 50 mg sodium salicylate increased from 73.2 +/- 27.8% to 121.4 +/- 102.7% reduction, but the RH did not change significantly. Insulin capsules containing polyoxyethylene-9-lauryl ether (POELE) used in its optimum concentration (2%), found in these experiments, produced RH of 9.5 +/- 6.8% when prepared as granules by wetting with a few drops of absolute alcohol in the presence of PC (50 mg). Insulin capsules containing lower (1%) or higher (3%) concentrations of POELE and prepared with PC, 50 mg by wet granulation produced lower RH of about 6%. The enteric-coated oral insulin capsules containing insulin (6 or 9 U/kg) and sodium salicylate (50 mg) as an absorption promoter, together with the bioadhesive polymer polycarbophil (50 mg), and prepared either by wet granulation using ethanol or by freeze-drying, are the best formulations to be used. They achieved a reduction in plasma glucose levels of about 25-30% and RH of about 10%. Also insulin (9 U/kg) capsules containing 2% POELE produced a 28% reduction in plasma glucose levels and RH of 9.6 +/- 6.8%.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Acrylic Resins,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Pharmaceutic,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Methylcellulose,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Salicylate,
http://linkedlifedata.com/resource/pubmed/chemical/Tablets, Enteric-Coated,
http://linkedlifedata.com/resource/pubmed/chemical/calcium polycarbophil,
http://linkedlifedata.com/resource/pubmed/chemical/carbopol 934P,
http://linkedlifedata.com/resource/pubmed/chemical/hypromellose,
http://linkedlifedata.com/resource/pubmed/chemical/polidocanol
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0363-9045
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
28
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
563-70
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12098845-Acrylates,
pubmed-meshheading:12098845-Acrylic Resins,
pubmed-meshheading:12098845-Adjuvants, Pharmaceutic,
pubmed-meshheading:12098845-Administration, Oral,
pubmed-meshheading:12098845-Animals,
pubmed-meshheading:12098845-Blood Glucose,
pubmed-meshheading:12098845-Capsules,
pubmed-meshheading:12098845-Diabetes Mellitus, Experimental,
pubmed-meshheading:12098845-Dogs,
pubmed-meshheading:12098845-Drug Carriers,
pubmed-meshheading:12098845-Drug Compounding,
pubmed-meshheading:12098845-Hypoglycemic Agents,
pubmed-meshheading:12098845-Injections, Subcutaneous,
pubmed-meshheading:12098845-Insulin,
pubmed-meshheading:12098845-Male,
pubmed-meshheading:12098845-Methylcellulose,
pubmed-meshheading:12098845-Polyethylene Glycols,
pubmed-meshheading:12098845-Sodium Salicylate,
pubmed-meshheading:12098845-Tablets, Enteric-Coated
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effect of bioadhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether, and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs.
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| pubmed:affiliation |
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ehosny@ksu.edu.sa
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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