Linked Life Data

12098010

Source:http://linkedlifedata.com/resource/pubmed/id/12098010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-7-4
pubmed:abstractText
Isolated perfused bovine uteri were used to study the irritation potential of antiseptics frequently used in veterinary practice for the treatment of endometritis. Comparable to the isolated perfused bovine udder (Kietzmann et al., 1993), the viability of uteri obtained directly after slaughtering of cows, was tested with the help of biochemical parameters. These parameters of the viability were nearly unchanged over five hours. Thereafter, different antiseptics were tested for their irritation potential on the mucous membrane with the help of the MTT-assay. Here the irritant effect of Lugol's iodine solution is demonstrated exemplarily. An additional study was performed to establish a hemoperfused uterus. An injection of arachidonic acid into the serosa induces a visible inflammatory reaction and a marked increase of the prostaglandin E2 synthesis. In conclusion, the isolated perfused bovine uterus seems to be a promising in vitro model for mucous membrane irritancy as well as for inflammatory reactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1868-596X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-63
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The isolated perfused bovine uterus as a model for mucous membrane irritation and inflammation.
pubmed:affiliation
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Hochschule Hannover, D-Hannover, Germany.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't