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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-7-4
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pubmed:abstractText |
The purpose of this study was to evaluate the relationship between attention deficit hyperactivity disorder (ADHD) and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 71 patients with ADHD and 128 healthy controls. The 5-HTTLPR S/S genotype was significantly lower in the patients than in the controls (p = 0.018). Homozygous and heterozygous L variant predominated in the ADHD group. But the VNTR STin2.12/12 genotype was significantly less found in the patients than in the controls (p = 0.001). There was no significant difference between the frequency of the short (S), long, 10, and 12 alleles of both groups. The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0302-282X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-81
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12097805-Adolescent,
pubmed-meshheading:12097805-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:12097805-Carrier Proteins,
pubmed-meshheading:12097805-Case-Control Studies,
pubmed-meshheading:12097805-Child,
pubmed-meshheading:12097805-Female,
pubmed-meshheading:12097805-Genotype,
pubmed-meshheading:12097805-Humans,
pubmed-meshheading:12097805-Male,
pubmed-meshheading:12097805-Membrane Glycoproteins,
pubmed-meshheading:12097805-Membrane Transport Proteins,
pubmed-meshheading:12097805-Nerve Tissue Proteins,
pubmed-meshheading:12097805-Polymerase Chain Reaction,
pubmed-meshheading:12097805-Polymorphism, Genetic,
pubmed-meshheading:12097805-Serotonin,
pubmed-meshheading:12097805-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:12097805-Tandem Repeat Sequences,
pubmed-meshheading:12097805-Turkey
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pubmed:year |
2002
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pubmed:articleTitle |
Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder.
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pubmed:affiliation |
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Gaziantep University, Kolejtepe, Gaziantep, Turkey. zoroglus@hotmail.com
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pubmed:publicationType |
Journal Article
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