Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2002-7-4
pubmed:abstractText
The publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ends onto the genome by use of the raw data generated by the expressed sequence tag (EST) sequencing projects. We find that at least half of the human genes encode multiple transcripts whose polyadenylation is driven by multiple signals. The corresponding transcript 3' ends are spread over distances in the kilobase range. This finding has profound implications for our understanding of gene expression regulation and of the diversity of human transcripts, for the design of cDNA microarray probes, and for the interpretation of gene expression profiling experiments.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10072078, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10199393, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10369871, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10409702, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10521335, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10547834, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10554005, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10591208, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10689348, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10830953, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-10872821, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-11181992, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-11242095, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-11292841, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-11544195, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-11593022, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-7265238, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-7929587, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-8889550, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-9521921, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-9582195, http://linkedlifedata.com/resource/pubmed/commentcorrection/12097343-9750195
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1088-9051
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1068-74
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Long-range heterogeneity at the 3' ends of human mRNAs.
pubmed:affiliation
Office of Information Technology, Ludwig Institute for Cancer Research, Switzerland.
pubmed:publicationType
Letter