Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-7-2
pubmed:abstractText
Heat shock proteins (hsps) are induced in a variety of cells following periods of stress, where they promote cell survival. In this study, we examined the effect of upregulating hsp expression by treatment with BRX-220, a co-inducer of hsps, on the survival of injured motoneurones. Following sciatic nerve crush at birth, rat pups were treated daily with BRX-220. The expression of hsp70 and hsp90, motoneurone survival, and muscle function was examined at various intervals later and the number of functional motor units was assessed by in vivo isometric tension recordings. Fourteen days after injury, significantly more motoneurones survived in the BRX-220-treated group (39 +/- 2.8%) compared to the saline-treated group (21 +/- 1.7%). Moreover, in the BRX-220-treated group no further loss of motoneurones occurred, so that at 10 weeks 42 +/- 2.1% of motoneurones survived compared to 15 +/- 0.6% in the untreated group. There were also more functional motor units in the hindlimb muscles of BRX-220-treated animals. In addition, treatment with BRX-220 resulted in a significant increase in the expression of hsp70 and hsp90 in glia and neurones. Thus, treatment with BRX-220, a co-inducer of hsps, protects motoneurones from axotomy-induced cell death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-97
pubmed:dateRevised
2010-11-2
pubmed:meshHeading
pubmed-meshheading:12093085-Animals, pubmed-meshheading:12093085-Animals, Newborn, pubmed-meshheading:12093085-Axotomy, pubmed-meshheading:12093085-Blotting, Western, pubmed-meshheading:12093085-Cell Count, pubmed-meshheading:12093085-Cell Death, pubmed-meshheading:12093085-Cell Survival, pubmed-meshheading:12093085-Drug Administration Schedule, pubmed-meshheading:12093085-Drug Evaluation, Preclinical, pubmed-meshheading:12093085-Female, pubmed-meshheading:12093085-HSP70 Heat-Shock Proteins, pubmed-meshheading:12093085-HSP90 Heat-Shock Proteins, pubmed-meshheading:12093085-Heat-Shock Proteins, pubmed-meshheading:12093085-Hydroxylamines, pubmed-meshheading:12093085-Immunohistochemistry, pubmed-meshheading:12093085-Isometric Contraction, pubmed-meshheading:12093085-Male, pubmed-meshheading:12093085-Motor Neurons, pubmed-meshheading:12093085-Muscle Contraction, pubmed-meshheading:12093085-Nerve Crush, pubmed-meshheading:12093085-Neuroprotective Agents, pubmed-meshheading:12093085-Rats, pubmed-meshheading:12093085-Rats, Sprague-Dawley, pubmed-meshheading:12093085-Up-Regulation
pubmed:year
2002
pubmed:articleTitle
Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats.
pubmed:affiliation
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't