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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-2
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pubmed:abstractText |
Several mechanisms control discrimination between self and non-self, including the thymic deletion of autoreactive T cells and the induction of anergy in the periphery. In addition to these passive mechanisms, evidence has accumulated for the active suppression of autoreactivity by a population of regulatory or suppressor T cells that co-express CD4 and CD25 (the interleukin-2 receptor alpha-chain). CD4+ CD25+ T cells are powerful inhibitors of T-cell activation both in vivo and in vitro. The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1474-1733
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-400
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12093005-Animals,
pubmed-meshheading:12093005-Antigen-Presenting Cells,
pubmed-meshheading:12093005-Antigens, CD,
pubmed-meshheading:12093005-Antigens, CD4,
pubmed-meshheading:12093005-Antigens, Differentiation,
pubmed-meshheading:12093005-CTLA-4 Antigen,
pubmed-meshheading:12093005-Cytokines,
pubmed-meshheading:12093005-Homeostasis,
pubmed-meshheading:12093005-Humans,
pubmed-meshheading:12093005-Immune Tolerance,
pubmed-meshheading:12093005-Immunoconjugates,
pubmed-meshheading:12093005-Lymphocyte Activation,
pubmed-meshheading:12093005-Mice,
pubmed-meshheading:12093005-Models, Immunological,
pubmed-meshheading:12093005-Rats,
pubmed-meshheading:12093005-Receptors, Interleukin-2,
pubmed-meshheading:12093005-T-Lymphocytes, Regulatory,
pubmed-meshheading:12093005-Thymus Gland,
pubmed-meshheading:12093005-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
CD4+ CD25+ suppressor T cells: more questions than answers.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. EShevach@niaid.nih.gov
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pubmed:publicationType |
Journal Article,
In Vitro,
Review
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